Protein Details: Aquaporin-2

Protein ID

ICDB_Pro_0483

Protein Name

Aquaporin-2

Gene Name

Aqp2

Organism

Rattus norvegicus (Rat)

Length

271 amino acids

AlphaFoldDB

AF-P34080-F1-model_v4.pdb

Function

Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water;thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis (By similarity).

Sequence

MWELRSIAFSRAVLAEFLATLLFVFFGLGSALQWASSPPSVLQIAVAFGLGIGILVQALGHVSGAHINPAVTVACLVGCHVSFLRAAFYVAAQLLGAVAGAAILHEITPVEIRGDLAVNALHNNATAGQAVTVELFLTMQLVLCIFASTDERRGDNLGSPALSIGFSVTLGHLLGIYFTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAIIGSLLYNYLLFPSAKSLQERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGSKA

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

endotoxemia; Acute kidney injury

Location

Detected in kidney;in cortical and the medullary collecting tubules (at protein level) (PubMed:8429910). Detected in kidney medulla and cortex (PubMed:7508187;PubMed:8429910).

DOI ID

10.1038/361549a0; 10.1006/bbrc.1993.2529; 10.1152/ajpcell.1994.266.1.c189; 10.1101/gr.2596504; 10.1073/pnas.0600895103; 10.1152/ajpcell.00098.2009; 10.1038/ncomms1871

RefSeq

NP_037041.2